Study M671
Study name | Xu SH 2020 |
Title | Chronic stress in a rat model of depression disturbs the glutamine-glutamate-GABA cycle in the striatum, hippocampus, and cerebellum |
Overall design | In this study, a gas chromatography-mass spectrometer (GC/MS)-based metabolomic analysis was performed in the striatum of depressed rats induced by chronic unpredictable mild stress (CUMS). Sprague-Dawley rats were divided into the following 2 groups: (1) control group, and (2) CUMS group. The CUMS stress procedure lasted for 4 weeks. Eight samples per group were used for metabonomic analysis. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Rat; Sprague-Dawley rat; |
Categories of depression | Animal model; Chronic mild stress model; Chronic mild stress model; |
Criteria for depression | Sucrose preference test, forced swimming test |
Sample size | 16 |
Tissue | Central; Brain; Striatum; |
Platform | MS-based; GC-MS: Agilent 7890A/5975C GC/MSD system (Agilent Technologies Inc., USA); |
PMID | |
DOI | |
Citation | Xu S, Liu Y, Pu J, et al. Chronic stress in a rat model of depression disturbs the glutamine-glutamate-GABA cycle in the striatum, hippocampus, and cerebellum. Neuropsychiatr Dis Treat. 2020;16:557-570. |
Metabolite | Stearic acid; L-Leucine; Glycine; L-Glutamine; Fructose 6-phosphate; Ethanolamine; Beta-Alanine; Dihydroxyacetone phosphate; Pyrophosphate; D-Ribose 5-phosphate; Glycerol 3-phosphate; L-Cystathionine; Thymine; Mannose 6-phosphate; Epsilon-caprolactam; Guanine; Carbamic acid; |
