Study M667
Study name | Xiao QF 2020 |
Title | Crocin-I alleviates the depression-like behaviors probably via modulating "microbiota-gut-brain" axis in mice exposed to chronic restraint stress |
Overall design | The aim of this study was to investigate whether the gut microbiota was involved in the effects of crocin-I on depression in a mice model of depression induced by chronic restraint stress (CRS). C57BL/6 J mice were divided into the following 3 groups: (1) control group, (2) CRS group, and (3) CRS + crocin-I group (stressor plus crocin-I treatment at the dose of 40 mg/kg). The CRS stress procedure lasted for 10 weeks, and drugs were administered via intragastric once per day during the last 6 weeks of the model building period. Fecal samples were used to determination of short-chain fatty acids (SCFAs) by gas chromatography-mass spectrometry (n = 4 per group). |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Mouse; C57BL/6 J mouse; |
Categories of depression | Animal model; Chronic restraint stress model; Chronic restraint stress model; |
Criteria for depression | Sucrose preference test, forced swimming test, tail suspension test |
Sample size | 12 |
Tissue | Peripheral; Faece; Faece; |
Platform | MS-based; GC-MS: Shimadzu GC-14B gas chromatograph with mass spectrometry; |
PMID | |
DOI | |
Citation | Xiao Q, Shu R, Wu C, et al. Crocin-I alleviates the depression-like behaviors probably via modulating "microbiota-gut-brain" axis in mice exposed to chronic restraint stress. J Affect Disord. 2020;276:476-486. |
Metabolite |
