Study M664
Study name | Wang W 2020 |
Title | Dl-3-n-butylphthalide attenuates mouse behavioral deficits to chronic social defeat stress by regulating energy metabolism via AKT/CREB signaling pathway |
Overall design | The aim of this study was to investigate the effect of Dl-3-n-butylphthalide (NBP) in a chronic social defeat stress (CSDS) model of depression and its underlying molecular mechanisms. C57BL/6 J mice were divided into the following 3 groups: (1) control group (vehicle treatment, n = 12), (2) CSDS group (stressor plus vehicle treatment, n = 15), and (3) CSDS + Dl-3-n-butylphthalide group (stressor plus Dl-3-n-butylphthalide treatment at the dose of 60 mg/kg, n = 13). The CSDS stress procedure lasted for 10 days, and drugs were administered via intragastric once per day during the model building period. The targeted metabolomics approach, based on LC-MS, was used to obtain total metabolic data for the hippocampus and prefrontal cortex (n = 5 per group). |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Mouse; C57BL/6 J mouse; |
Categories of depression | Animal model; Social defeat model; Social defeat model; |
Criteria for depression | Social interaction test, sucrose preference test, tail suspension test |
Sample size | 15 |
Tissue | Central; Brain; Prefrontal cortex; Central; Brain; Hippocampus; |
Platform | MS-based; LC-MS: Agilent 1290 Infinity chromatography system and AB SCIEX QTRAP 5500 mass spectrometer; |
PMID | |
DOI | |
Citation | Wang W, Wang T, Bai S, et al. Dl-3-n-butylphthalide attenuates mouse behavioral deficits to chronic social defeat stress by regulating energy metabolism via AKT/CREB signaling pathway. Transl Psychiatry. 2020;10(1):49. |
Metabolite | Citric acid; Succinic acid; Glucose 6-phosphate; Isocitric acid; Guanosine triphosphate; Dihydroxyacetone phosphate; 3-Phosphoglyceric acid; NAD; NADP; Guanosine monophosphate; |
