Study M660
Study name | Wang JC 2020 |
Title | Application of 1 H-MRS in end-stage renal disease with depression |
Overall design | The aim of this study was to investigate the metabolite changes in the frontal lobe of the end-stage renal disease (ESRD) patients with depression using proton magnetic resonance spectroscopy (1H-MRS). All subjects were divided into three groups: ESRD patients with depression (ESRD with depression, n = 30), ESRD patients without depression (ESRD without depression, n = 27) and normal subjects (control group, n = 32). ESRD with depression patients were further divided into two groups according to the severity of depression: 14 cases of ESRD with severe depression group (Hamilton Depression Rating Scale (HAMD) score >= 35) and 16 cases of ESRD with mild to moderate depression group (20 =< HAMD score < 35). 1H-MRS was used in brain regions of all subjects to measure N-acetylaspartate/creatine (NAA/Cr), choline-containing compounds/creatine (Cho/Cr) and myo-inositol/creatine (MI/Cr) ratios of the frontal lobe. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive symptom; Depressive symptom with comorbidity; Depressive symptom with comorbidity; |
Criteria for depression | HAMD-17 >= 20 |
Sample size | 89 |
Tissue | Central; Brain; Frontal lobe; |
Platform | MRS; MRS: GE Signa 3.0 T whole-body scanner; |
PMID | |
DOI | |
Citation | Wang J, Zhou T, Liu J, et al. Application of 1 H-MRS in end-stage renal disease with depression. BMC Nephrol. 2020;21(1):225. |
Metabolite | N-Acetyl aspartate/(Creatine and Phosphocreatine) ratio; Choline-containing compounds/(Creatine and Phosphocreatine) ratio; |
