Study M656
Study name | Streeter CC 2020 |
Title | Thalamic gamma aminobutyric acid level changes in major depressive disorder after a 12-week Iyengar yoga and coherent breathing intervention |
Overall design | The aim of this study was to determine if a 12-week yoga intervention was associated with increased gamma aminobutyric acid (GABA) levels and decreased depressive symptoms in participants with major depressive disorder (MDD). Subjects were randomized to a high-dose group (HDG) of three yoga interventions a week and a low-dose group (LDG) of two yoga interventions a week. Thalamic GABA levels were obtained using magnetic resonance spectroscopy at Scan-1 before randomization. After the assigned 12-week intervention, Scan-2 was obtained, immediately followed by a yoga intervention and Scan-3. Beck Depression Inventory II (BDI-II) scores were obtained before Scan-1 and Scan-3. Metabolite quantification was reported relative to total creatine as the reference peak. |
Study Type | Type2; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Depression; Depression; |
Criteria for depression | DSM-IV diagnosed MDD, BDI-II >= 14 to < 28 |
Sample size | 28 |
Tissue | Central; Brain; Thalamus; |
Platform | MRS; MRS: 4.0-Tesla Varian Unity/INOVA whole-body MRI/MRS scanner (Varian, Inc., Palo Alto, CA); |
PMID | |
DOI | |
Citation | Streeter CC, Gerbarg PL, Brown RP, et al. Thalamic gamma aminobutyric acid level changes in major depressive disorder after a 12-week Iyengar yoga and coherent breathing intervention. J Altern Complement Med. 2020;26(3):190-197. |
Metabolite |
