Study M655
Study name | Sendur I 2020 |
Title | Study on dorsolateral prefrontal cortex neurochemical metabolite levels of patients with major depression using H-MRS technique |
Overall design | The aim of this study was to investigate the effects of major depression on the biochemistry of the brain, the relationship between the parametric changes demonstrated and cognitive functions, and the effects of antidepressant treatment by using proton magnetic resonance spectroscopy (1H-MRS). The study included 30 patients, diagnosed with moderate/severe non-chronic major depression disorder (MDD group), and 30 healthy individuals as the control group. The dorsolateral prefrontal cortex (DLPFC) areas of the patients and the control individuals were scanned bilaterally by 1H-MRS. Metabolite quantification was reported relative to total creatine as the reference peak. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Depression; Depression; |
Criteria for depression | DSM-5 diagnosed MDD |
Sample size | 60 |
Tissue | Central; Brain; Dorsolateral prefrontal cortex; |
Platform | MRS; MRS: 1.5 Tesla Magnetic Resonance Spectroscope (GE Philips Ingenia; Philips Medical System, Best, Netherlands); |
PMID | |
DOI | |
Citation | Sendur I, Oguzhanoglu NK, Varma GS. Study on dorsolateral prefrontal cortex neurochemical metabolite levels of patients with major depression using H-MRS technique. Turk Psikiyatri Derg. 2020;31(2):75-83. |
Metabolite |
