Study M654
Study name | Seewoo BJ 2020 |
Title | Validation of chronic restraint stress model in young adult rats for the study of depression using longitudinal multimodal MR imaging |
Overall design | The aim of this study was to investigate the relationship between neurobiological and behavioral changes in the chronic restraint stress (CRS) rat model by performing multimodal MRI (rs-fMRI, 1H-MRS, and structural MRI) and behavioral tests on the same young adult male rats before and after induction of the model. Sprague-Dawley rats were divided into the following 2 groups: (1) control group, and (2) CRS group (chronic restraint for 13 days). The concentrations of GABA, glutamate (Glu), glutamine (Gln), and Glu-Gln (Glx) were measured before and after CRS. Metabolite quantification was reported relative to total creatine as the reference peak. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Rat; Sprague-Dawley rat; |
Categories of depression | Animal model; Chronic restraint stress model; Chronic restraint stress model; |
Criteria for depression | Sucrose preference test, forced swimming test |
Sample size | 24 |
Tissue | Central; Brain; Sensorimotor cortex; |
Platform | MRS; MRS: Bruker Biospec 94/30 small animal MRI system; |
PMID | |
DOI | |
Citation | Seewoo BJ, Hennessy LA, Feindel KW, et al. Validation of chronic restraint stress model in young adult rats for the study of depression using longitudinal multimodal MR imaging. eNeuro. 2020;7(4):ENEURO.0113-20.2020. |
Metabolite | (Glutamate and Glutamine)/(Creatine and Phosphocreatine) ratio; |
