Study M653

Study name

Saadat N 2020

Title

Lipidome profiles are related to depressive symptoms and preterm birth among African American women

Overall design

In this study, using an untargeted lipidome profiling method, the authors determined the molecular compositions of several hundred lipid analytes in plasma from 31 pregnant African American women and explored associations between lipidome profiles and both depressive symptoms and risk of preterm birth among these participants. For depressive symptoms, women were divided into depression group (CES-D scores >= 23. n= 8) and control group (CES-D scores < 22). Lipidomic profiles were determined by shotgun Orbitrap high-resolution/accurate mass spectrometry.

Study Type

Type1;

Data available

Unavailable

Organism

Human;

Categories of depression

Depressive symptom; Depressive symptom; Depressive symptom;

Criteria for depression

CES-D >= 17

Sample size

26

Tissue

Peripheral; Blood; Plasma;

Platform

MS-based; LC-MS: LTQ-Orbitrap Velos MS (Thermo Scientific, Waltham, MA);

PMID

32383404

DOI

10.1177/1099800420923032

Citation

Saadat N, Lydic TA, Misra DP, et al. Lipidome profiles are related to depressive symptoms and preterm birth among African American women. Biol Res Nurs. 2020;22(3):354-361.

Metabolite

PC(36:1);

PC(O-42:6);

PC(44:10);

PE(34:00);

PG(16:00);

CE(14:0);

PC(37:1);

PC(46:12);

PCox(24:0);