Study M651
Study name | Peng Y 2020 |
Title | Fish oil alleviates LPS-induced inflammation and depressive-like behavior in mice via restoration of metabolic impairments |
Overall design | In this study, the metabolomic technique was applied to investigate the potential involvement of fish oil (FO) metabolites in ameliorating depressive-like behaviors in lipopolysaccharides (LPS)-injected mice. C57BL/6 mice were divided into the following 3 groups: (1) control group (vehicle, n = 10), (2) LPS group (an intraperitoneal injection of LPS at a dose of 1 mg/kg, n = 8), and (3) LPS + fish oil group (daily intragastric administration of fish oil before LPS injection for 14 days, and then received an intraperitoneal injection of LPS at a dose of 1 mg/kg, n = 8). Plasma and whole brain samples were used for metabolomics analysis. |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Mouse; C57BL/6 mouse; |
Categories of depression | Animal model; Lipopolysaccharide induced depression model; Lipopolysaccharide induced depression model; |
Criteria for depression | Sucrose preference test, tail suspension test, forced swimming test |
Sample size | 28 |
Tissue | Peripheral; Blood; Plasma; Central; Brain; Brain; |
Platform | MS-based; LC-MS: Waters Acquity UPLC (Waters, Milford, MA, USA) with a Waters SYNAPT G2-Si High Definition Mass Spectrometry (HDMS) instrument; |
PMID | |
DOI | |
Citation | Peng Y, Shi Z, Satyanarayanan SK, et al. Fish oil alleviates LPS-induced inflammation and depressive-like behavior in mice via restoration of metabolic impairments. Brain Behav Immun. 2020;90:393-402. |
Metabolite | Tyramine; LysoPC(16:0); Uric acid; DOPA; Taurine; Hypotaurine; Glyceric acid 1,3-biphosphate; NAD; Oxidized glutathione; Deoxyadenosine; Nicotinic acid; ADP; Cysteinylglycine; Prostaglandin E2; 20-Hydroxyeicosatetraenoic acid; DL-Glutamate; Homovanillin; |
