Study M646

Study name

Mishra PK 2020

Title

Impaired neuronal and astroglial metabolic activity in chronic unpredictable mild stress model of depression: reversal of behavioral and metabolic deficit with lanicemine

Overall design

The aim of this study was to evaluate neural metabolic activity in prefrontal cortex (PFC) in C57BL6 mice undergoing a chronic unpredictable mild stress (CUMS) for three weeks to induce depression. C57BL/6J mice were divided into the following 2 groups: (1) control group (n = 30), and (2) CUMS group (n = 29). The CUMS stress procedure lasted for 3 weeks. Concentration of prefrontal cortex metabolites were compared in control and CUMS mice.

Study Type

Type1;

Data available

Unavailable

Organism

Mouse; C57BL/6J mouse;

Categories of depression

Animal model; Chronic mild stress model; Chronic mild stress model;

Criteria for depression

Sucrose preference test, forced swimming test

Sample size

59

Tissue

Central; Brain; Prefrontal cortex;

Peripheral; Blood; Plasma;

Platform

NMR; NMR: 600 MHz NMR spectrometer (AVANCE II, Bruker Biospin, Karlsruhe, Germany);

PMID

32360130

DOI

10.1016/j.neuint.2020.104750

Citation

Mishra PK, Adusumilli M, Deolal P, et al. Impaired neuronal and astroglial metabolic activity in chronic unpredictable mild stress model of depression: reversal of behavioral and metabolic deficit with lanicemine. Neurochem Int. 2020;137:104750.

Metabolite

L-Glutamic acid;

L-Glutamine;