Skip to main content

Study M644

Study name

Mezger E 2020

Title

Effects of bifrontal transcranial direct current stimulation on brain glutamate levels and resting state connectivity: multimodal MRI data for the cathodal stimulation site

Overall design

The aim of this study was to investigate the effects of bifrontal transcranial direct current stimulation (tDCS) on glutamate, glutamate + glutamine and GABA levels in a magnetic resonance spectroscopy (MRS) voxel close to the cathode over the right dorsolateral prefrontal cortex (DLPFC) before, during and after tDCS. Twenty subjects participated in a sham-controlled combined tDCS-MRS protocol and received active and sham tDCS in a double-blind cross-over design with randomized order. Four 10-min intervals of MRS were measured before (baseline), during (during1, during2) and after (post) tDCS. Metabolite quantification was reported relative to total creatine as the reference peak.

Study Type

Type3;

Data available

Unavailable

Organism

Human;

Categories of depression

Healthy individuals; Healthy individuals; Healthy individuals;

Criteria for depression

Not reported

Sample size

20

Tissue

Central; Brain; Dorsolateral prefrontal cortex;

Platform

MRS; MRS: 3 Tesla MRI scanner (Magnetom Skyra, Siemens Healthineers, Erlangen, Germany);

PMID

32743758

DOI

10.1007/s00406-020-01177-0

Citation

Mezger E, Rauchmann BS, Brunoni AR, et al. Effects of bifrontal transcranial direct current stimulation on brain glutamate levels and resting state connectivity: multimodal MRI data for the cathodal stimulation site. Eur Arch Psychiatry Clin Neurosci. 2020.

Metabolite

L-Glutamic acid;