Study name | Mezger E 2020 |
Title | Effects of bifrontal transcranial direct current stimulation on brain glutamate levels and resting state connectivity: multimodal MRI data for the cathodal stimulation site |
Overall design | The aim of this study was to investigate the effects of bifrontal transcranial direct current stimulation (tDCS) on glutamate, glutamate + glutamine and GABA levels in a magnetic resonance spectroscopy (MRS) voxel close to the cathode over the right dorsolateral prefrontal cortex (DLPFC) before, during and after tDCS. Twenty subjects participated in a sham-controlled combined tDCS-MRS protocol and received active and sham tDCS in a double-blind cross-over design with randomized order. Four 10-min intervals of MRS were measured before (baseline), during (during1, during2) and after (post) tDCS. Metabolite quantification was reported relative to total creatine as the reference peak. |
Type3; | |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Healthy individuals; Healthy individuals; Healthy individuals; |
Criteria for depression | Not reported |
Sample size | 20 |
Tissue | Central; Brain; Dorsolateral prefrontal cortex; |
Platform | MRS; MRS: 3 Tesla MRI scanner (Magnetom Skyra, Siemens Healthineers, Erlangen, Germany); |
PMID | |
DOI | |
Citation | Mezger E, Rauchmann BS, Brunoni AR, et al. Effects of bifrontal transcranial direct current stimulation on brain glutamate levels and resting state connectivity: multimodal MRI data for the cathodal stimulation site. Eur Arch Psychiatry Clin Neurosci. 2020. |
Metabolite |