Study M643
Study name | McNamara RK 2020 |
Title | Effects of fish oil monotherapy on depression and prefrontal neurochemistry in adolescents at high risk for bipolar I disorder: a 12-week placebo-controlled proton magnetic resonance spectroscopy trial |
Overall design | The aim of this study was to evaluate the clinical and neurochemical effects of 12-week fish oil, a source of omega-3 polyunsaturated fatty acids (n-3 PUFAs), in depressed adolescents with a family history of bipolar I disorder. Adolescents with depression were randomized to double-blind treatment with fish oil (fish oil group, 2100 mg/day) or placebo for 12 weeks (placebo group). A total of 42 patients completed the 12-week trial (placebo n = 21 and fish oil n = 21). Anterior cingulate cortex and bilateral ventrolateral prefrontal cortex neurometabolite concentrations were measured using proton magnetic resonance spectroscopy at 4 T at baseline and after treatment. Metabolite quantification was reported relative to brain water concentration. |
Study Type | Type2; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Pediatric depression; Pediatric depression; |
Criteria for depression | DSM-IV-TR diagnosed MDD or Depressive Disorder NOS, CDRS-R >=40 |
Sample size | 42 |
Tissue | Central; Brain; Ventrolateral prefrontal cortex; Central; Brain; Anterior cingulate cortex; |
Platform | MRS; MRS: Varian 4T whole-body scanner; |
PMID | |
DOI | |
Citation | McNamara RK, Strawn JR, Tallman MJ, et al. Effects of fish oil monotherapy on depression and prefrontal neurochemistry in adolescents at high risk for bipolar I disorder: a 12-week placebo-controlled proton magnetic resonance spectroscopy trial. J Child Adolesc Psychopharmacol. 2020;30(5):293-305. |
Metabolite |
