Study M642
Study name | Matsuda Y 2020 |
Title | Ergothioneine, a metabolite of the gut bacterium Lactobacillus reuteri, protects against stress-induced sleep disturbances |
Overall design | In this study, the authors analyzed changes in gut microbiota and their sulfur metabolites in the feces of a depression rat model using the modified 14-day social defeat stress (SDS) paradigm. Sprague-Dawley rats were divided into the following 2 groups: (1) control group, and (2) SDS group. The SDS stress procedure lasted for 2 weeks. Fecal and blood samples were used for sulfur metabolomics analysis. Six samples per group were used for metabonomic analysis. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Rat; Sprague-Dawley rat; |
Categories of depression | Animal model; Social defeat model; Social defeat model; |
Criteria for depression | Social interaction test |
Sample size | 12 |
Tissue | Peripheral; Faece; Faece; Peripheral; Blood; Plasma; |
Platform | MS-based; LC-MS: LC-MS/MS (Shimadzu Nexera UHPLC system with on-line LCMS 8040, Kyoto, Japan); |
PMID | |
DOI | |
Citation | Matsuda Y, Ozawa N, Shinozaki T, et al. Ergothioneine, a metabolite of the gut bacterium Lactobacillus reuteri, protects against stress-induced sleep disturbances. Transl Psychiatry. 2020;10(1):170. |
Metabolite |
