Study M638

Study name

Liu XJ 2020d

Title

Correlations among mRNA expression levels of ATP7A, serum ceruloplasmin levels and neuronal metabolism in unmedicated major depressive disorder

Overall design

The aim of this study was to explore the correlations among the mRNA expression levels of ATP7A, serum ceruloplasmin levels, and neuronal biochemical metabolism of copper-rich cerebral regions in major depressive disorder (MDD) patients. A total of 31 MDD patients (MDD group) and 21 age- and gender-matched healthy control (control group) participants were recruited. The levels of N-acetylaspartate/creatine and choline/creatine were assessed. Metabolite quantification was reported relative to total creatine as the reference peak.

Study Type

Type1;

Data available

Unavailable

Organism

Human;

Categories of depression

Depressive disorder; Depression; Depression;

Criteria for depression

DSM-5 diagnosed MDD, HAMD-24 >= 20

Sample size

52

Tissue

Central; Brain; Prefrontal white matter;

Central; Brain; Cerebellum;

Central; Brain; Lentiform nucleus;

Central; Brain; Anterior cingulate cortex;

Central; Brain; Thalamus;

Platform

MRS; MRS: Discovery MR 750 3.0T MRI scanner (General Electric, Milwaukee, WI);

PMID

32427278

DOI

10.1093/ijnp/pyaa038

Citation

Liu X, Zhong S, Yan L, et al. Correlations among mRNA expression levels of ATP7A, serum ceruloplasmin levels and neuronal metabolism in unmedicated major depressive disorder. Int J Neuropsychopharmacol. 2020;pyaa038.

Metabolite

Choline-containing compounds/(Creatine and Phosphocreatine) ratio;