Study M637
Study name | Liu XJ 2020c |
Title | Serum copper and zinc levels correlate with biochemical metabolite ratios in the prefrontal cortex and lentiform nucleus of patients with major depressive disorder |
Overall design | The aim of this study was to correlate copper and zinc levels with biochemical metabolite ratios in the prefrontal cortex (PFC) and lentiform nucleus (LN) of major depressive disorder (MDD) patients. Twenty-nine MDD patients (MDD group) and thirty-two age- and gender-matched healthy control volunteers (control group) were recruited. Proton magnetic resonance spectroscopy was used to determine the levels of the N-acetylaspartate, choline and creatine in the brain, and specifically in the PFC and LN regions. Metabolite quantification was reported relative to total creatine as the reference peak. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Depression; Depression; |
Criteria for depression | DSM-5 diagnosed MDD, HAMD-24 >= 20 |
Sample size | 61 |
Tissue | Central; Brain; Prefrontal cortex; Central; Brain; Lentiform nucleus; |
Platform | MRS; MRS: Discovery MR 750 3.0 T MRI scanner (General Electric, Milwaukee, WI, USA); |
PMID | |
DOI | |
Citation | Liu X, Zhong S, Li Z, et al. Serum copper and zinc levels correlate with biochemical metabolite ratios in the prefrontal cortex and lentiform nucleus of patients with major depressive disorder. Prog Neuropsychopharmacol Biol Psychiatry. 2020;99:109828. |
Metabolite |
