Study M636
Study name | Liu XJ 2020b |
Title | Deciphering the compatibility rules of traditional Chinese medicine prescriptions based on NMR metabolomics: a case study of Xiaoyaosan |
Overall design | In this study, taking Xiaoyaosan and its antidepressant effects as an example, the authors aimed to investigate the compatibility rules of Chinese medicine prescriptions adopting the research strategy of "Efficacy Compositions" and the approach of metabolomics. The XYS prescription was divided into two efficacy groups, i.e. Shugan group and Jianpi group. Meanwhile, the chronic unpredictable mild stress (CUMS)-induced depression model, a classical depression model, was constructed. Sprague-Dawley rats were divided into the following 4 groups (n = 6 in each group): (1) control group, (2) CUMS group, (3) CUMS + Xiaoyaosan group (stressor plus Xiaoyaosan treatment at the dose of 46.3 g/kg), and (4) CUMS + Shugan group (stressor plus Shugan treatment at the dose of 25.0 g/kg). The CUMS stress procedure lasted for 4 weeks, and drugs were administered via intragastric once per day during the model building period. |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Rat; Sprague-Dawley rat; |
Categories of depression | Animal model; Chronic mild stress model; Chronic mild stress model; |
Criteria for depression | Sucrose preference test |
Sample size | 24 |
Tissue | Peripheral; Faece; Faece; |
Platform | NMR; NMR: Bruker 600-MHz AVANCE III NMR spectrometer (Bruker Biospin, Rheinstetten, Germany); |
PMID | |
DOI | |
Citation | Liu X, Lv M, Wang Y, et al. Deciphering the compatibility rules of traditional Chinese medicine prescriptions based on NMR metabolomics: a case study of Xiaoyaosan. J Ethnopharmacol. 2020;254:112726. |
Metabolite | L-Phenylalanine; L-Proline; |
