Study M635
Study name | Liu XJ 2020a |
Title | Plasma metabolomics of depressed patients and treatment with Xiaoyaosan based on mass spectrometry technique |
Overall design | In this study, a GC-MS based metabolomics approach was applied to discover the potential biomarkers that were related to metabolic differences between healthy volunteers and depression cohort diagnosed by Hamilton Depression Scale (HAMD) and Clinical Global Impression scale (CGI), and to demonstrate the potential utility of these biomarkers in the diagnosis of depression and pharmaceutical efficacy of Xiaoyaosan. A total of 17 depressed patients (depression group) and the 17 age- and gender-matched healthy subjects (control group) were served as the primary cohort. Each of the depressed subjects took one dose of Xiaoyaosan prescription per day for eight weeks. In addition, five other depressed patients were also enrolled as the primary cohort when the final step of sample collection was conducted. Plasma samples were analyzed by Gas Chromatography-Mass Spectrometry (GC-MS). |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Depression; Depression; |
Criteria for depression | CCMD-3 diagnosed MDD, HAMD-17 between 17 and 24 |
Sample size | 39 |
Tissue | Peripheral; Blood; Plasma; |
Platform | MS-based; GC-MS: Agilent (J&W Scientific, Folsom, CA) with Thermo PolarisQ Ion Trap mass spectrometer (Thermo Fisher Scientific Inc., MA, USA); |
PMID | |
DOI | |
Citation | Liu X, Liu C, Tian J, et al. Plasma metabolomics of depressed patients and treatment with Xiaoyaosan based on mass spectrometry technique. J Ethnopharmacol. 2020;246:112219. |
Metabolite |
