Study M634
Study name | Liu XH 2020 |
Title | Polyunsaturated fatty acid supplement alleviates depression-incident cognitive dysfunction by protecting the cerebrovascular and glymphatic systems |
Overall design | The aim of this study was to test the prediction that the chronic unpredictable mild stress (CUMS) mouse model would manifest in disturbed glymphatic function and that dietary supplementation with polyunsaturated fatty acids (PUFA) could ameliorate these deficits while alleviating the depression-associated cognitive decline. C57BL/6 mice were divided into the following 4 groups: (1) control group, (2) CUMS group (stressor for 8 weeks), (3) CUMS + PUFA group (stressor plus PUFA mixed mice chow for 8 weeks), and (4) CUMS + escitalopram group (stressor for 8 weeks, plus fluoxetine treatment at the dose of 10 mg/kg intraperitoneal, during the last 4 weeks of modeling). Levels of dopamine, 5-hydroxytryptamine and noradrenaline in the prefrontal cortex microdialysates were determined by LC-MS (n = 5 mice per group). Five samples per group were used for metabonomic analysis. |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Mouse; C57BL/6 mouse; |
Categories of depression | Animal model; Chronic mild stress model; Chronic mild stress model; |
Criteria for depression | Tail suspension test, sucrose preference test |
Sample size | 20 |
Tissue | Central; Cerebrospinal fluid; Cerebrospinal fluid; |
Platform | MS-based; LC-MS: Agilent 1100 series high-performance LC (HPLC) system (Agilent Technologies, Santa Clara, CA, USA) with Bruker Apex-Qe 9.4-T Fourier transform ion cyclotron resonance (FTICR) MS (Bruker, Billerica, MA); |
PMID | |
DOI | |
Citation | Liu X, Hao J, Yao E, et al. Polyunsaturated fatty acid supplement alleviates depression-incident cognitive dysfunction by protecting the cerebrovascular and glymphatic systems. Brain Behav Immun. 2020;89:357-370. |
Metabolite |
