Study M626
Study name | Lewis CP 2020 |
Title | Altered anterior cingulate glutamatergic metabolism in depressed adolescents with current suicidal ideation |
Overall design | The aim of this study was to quantify anterior cingulate cortex (ACC) glutamatergic concentrations and to examine relationships with suicidal ideation (SI) in a sample of healthy and depressed adolescents. Forty adolescents underwent clinical evaluation and proton magnetic resonance spectroscopy (1H-MRS) at 3 T. Cerebrospinal fluid-corrected ACC metabolite concentrations were compared between healthy control (control group, n = 16), depressed without SI (depressed without suicidal ideation group, n = 13), and depressed with SI (depressed with suicidal ideation group, n = 11) youth. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Pediatric depression; Pediatric depression; |
Criteria for depression | K-SADS-PL diagnosed MDD, CDRS-R raw scores >= 35 |
Sample size | 40 |
Tissue | Central; Brain; Anterior cingulate cortex; |
Platform | MRS; MRS: General Electric 3 T Discovery 750 scanner (GE Healthcare, Chicago, IL, USA); |
PMID | |
DOI | |
Citation | Lewis CP, Port JD, Blacker CJ, et al. Altered anterior cingulate glutamatergic metabolism in depressed adolescents with current suicidal ideation. Transl Psychiatry. 2020;10(1):119. |
Metabolite |
