Study M625
Study name | Leclercq S 2020 |
Title | Gut microbiota-induced changes in beta-hydroxybutyrate metabolism are linked to altered sociability and depression in alcohol use disorder |
Overall design | In this study, the molecular mechanisms behind the gut microbiota-brain interactions were evaluated by using a preclinical model consisting of fecal microbiota transplantation (FMT) from alcohol use disorder (AUD) versus healthy subjects in mice, by using a metabolomics approach, and by evaluating the neuroactive impact of the modulation of a selected metabolite. C57BL/6J mice were divided into the following 2 groups: (1) control group (fecal microbiota transplantation from healthy controls), and depression group (fecal microbiota transplantation from patients with AUD). Twelve plasma samples per group were used for NMR-based metabonomic analysis. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Mouse; C57BL/6J mouse; |
Categories of depression | Animal model; Other animal model; Other animal model; |
Criteria for depression | Forced swimming test |
Sample size | 24 |
Tissue | Peripheral; Blood; Plasma; |
Platform | NMR; NMR: Bruker 600 spectrometer (14.1 T); |
PMID | |
DOI | |
Citation | Leclercq S, Roy TL, Furgiuele S, et al. Gut microbiota-induced changes in beta-hydroxybutyrate metabolism are linked to altered sociability and depression in alcohol use disorder. Cell Rep. 2020;33(2):108238. |
Metabolite |
