Skip to main content

Study M624

Study name

Kotb MA 2020

Title

Value of magnetic resonance spectroscopy in geriatric patients with cognitive impairment

Overall design

The aim of this study was to study the difference of hippocampal and frontal white matter metabolites between patients with Alzheimer’s disease, mild cognitive impairment, and cognitive impairment associated with depression, and control subjects using magnetic resonance spectroscopy (MRS). Four groups were recruited, including Alzheimer’s disease group (n = 20), cognitive impairment with depression group (n = 23), mild cognitive impairment group (n = 15), and control group (n = 15).

Study Type

Type1;

Data available

Unavailable

Organism

Human;

Categories of depression

Depressive disorder; Depression with comorbidity; Depression with comorbidity;

Criteria for depression

DSM-V diagnosed depression

Sample size

38

Tissue

Central; Brain; Hippocampus;

Central; Brain; Frontal white matter;

Platform

MRS; MRS: 1.5 T Siemens Magnetom;

PMID

N/A

DOI

10.1186/s41983-020-0147-y

Citation

Kotb MA, Kamal AM, Aldossary NM, et al. Value of magnetic resonance spectroscopy in geriatric patients with cognitive impairment. The Egyptian Journal of Neurology, Psychiatry and Neurosurgery. 2020;56:10.

Metabolite

N-Acetyl-L-aspartic acid;

N-Acetyl aspartate/(Creatine and Phosphocreatine) ratio;