Study M620

Study name

Kahl KG 2020

Title

Altered neurometabolism in major depressive disorder: a whole brain 1 H-magnetic resonance spectroscopic imaging study at 3T

Overall design

The aim of this study was to analyze brain metabolite alterations of major depressive disorder (MDD) by using recently established whole brain spectroscopic imaging. Thirty-two inpatients with major depressive disorder (MDD group) and 32 on one-to-one basis matched healthy controls (control group) were included. Lobar and cerebellar metabolite concentrations of brain N-acetylaspartate, total choline, total creatine, glutamine, glutamate, and myo-inositol were assessed in patients and controls using 1H-whole brain spectroscopic imaging. Metabolite quantification was reported relative to brain water concentration.

Study Type

Type1;

Data available

Unavailable

Organism

Human;

Categories of depression

Depressive disorder; Depression; Depression;

Criteria for depression

DSM-IV diagnosed MDD

Sample size

64

Tissue

Central; Brain; Frontal lobe;

Central; Brain; Cerebellum;

Central; Brain; Temporal lobe;

Central; Brain; Parietal lobe;

Platform

MRS; MRS: 3T MR scanner (Verio, Siemens, Erlangen, Germany);

PMID

32169561

DOI

10.1016/j.pnpbp.2020.109916

Citation

Kahl KG, Atalay S, Maudsley AA, et al. Altered neurometabolism in major depressive disorder: a whole brain 1 H-magnetic resonance spectroscopic imaging study at 3T. Prog Neuropsychopharmacol Biol Psychiatry. 2020;101:109916.

Metabolite

N-Acetyl-L-aspartic acid;

L-Glutamic acid;

L-Glutamine;

Choline-containing compounds;

Creatine and Phosphocreatine;