Study M618
Study name | Jaddoa E 2020 |
Title | Effect of antidepressant drugs on the brain sphingolipid system |
Overall design | The aim of this study was to investigate the action of antidepressant drugs on sphingolipid levels in rat brain regions, plasma and in cultured mouse macrophages. Sprague-Dawley rats were divided into the following 8 groups (n = 12 in each group): (1) acute paroxetine control group (single injection of vehicle, i.p.), (2) acute paroxetine group (single injection of paroxetine at the dose of 5 mg/kg, i.p.), (3) chronic paroxetine control group (chronic injection of vehicle for 15 days, i.p.), (4) chronic paroxetine group (chronic injection of paroxetine for 15 days, at the dose of 5 mg/kg, i.p.), (5) acute desipramine control group (single injection of vehicle, i.p.), (6) acute desipramine group (single injection of desipramine at the dose of 10 mg/kg, i.p.), (7) chronic desipramine control group (chronic injection of vehicle for 15 days, i.p.), and (8) chronic desipramine group (chronic injection of desipramine for 15 days, at the dose of 10 mg/kg, i.p.). Hippocampus, prefrontal cortex, striatum, and plasma levels of sphingosine were analysed using LC-MS. |
Study Type | Type3; |
Data available | Unavailable |
Organism | Rat; Sprague-Dawley rat; |
Categories of depression | Healthy individuals; Healthy individuals; Healthy individuals; |
Criteria for depression | Not reported |
Sample size | 96 |
Tissue | Central; Brain; Hippocampus; Central; Brain; Prefrontal cortex; Peripheral; Blood; Plasma; Central; Brain; Striatum; |
Platform | MS-based; LC-MS: Agilent 1260 Infinity LC-system (Agilent Technologies) with on-line LC-MS detector; |
PMID | |
DOI | |
Citation | Jaddoa E, Masania J, Masiero E, et al. Effect of antidepressant drugs on the brain sphingolipid system. J Psychopharmacol. 2020;34(7):716-725. |
Metabolite |
