Study M617
Study name | Huang XX 2020 |
Title | Serum metabonomic study on the antidepressant-like effects of ellagic acid in a chronic unpredictable mild stress-induced mouse model |
Overall design | In this study, the effects and serum metabolomic analysis of ellagic acid against depression were investigated using a chronic unpredictable mild stress-induced (CUMS) model. C57BL/6 mice were divided into the following 3 groups (n = 12 in each group): (1) control group, (2) CUMS group, and (3) CUMS + ellagic acid group (stressor plus ellagic acid treatment at the dose of 100 mg/kg). The CUMS stress procedure lasted for 6 weeks, and drugs were administered via intragastric once per day during the model building period. Ellagic acid significantly ameliorated the CUMS-induced depression-like behaviors. Five serum samples per group were used for metabonomic analysis. |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Mouse; C57BL/6 mouse; |
Categories of depression | Animal model; Chronic mild stress model; Chronic mild stress model; |
Criteria for depression | Sucrose preference test, forced swimming test, tail suspension test |
Sample size | 15 |
Tissue | Peripheral; Blood; Serum; |
Platform | MS-based; LC-MS: Agilent ACQUITY Ultraperformance Liquid Chromatography-quadrupole Time-of-flight Mass Spectrometry (UPLC-Q-TOF-MS, G6540B); |
PMID | |
DOI | |
Citation | Huang X, Li W, You B, et al. Serum metabonomic study on the antidepressant-like effects of ellagic acid in a chronic unpredictable mild stress-induced mouse model. J Agric Food Chem. 2020;68(35):9546-9556. |
Metabolite | L-Arginine; Uric acid; L-Malic acid; Orotic acid; 2-Hydroxyethanesulfonate; N-Acetylserine; 4-Imidazolone-5-propionic acid; Isoglutamine; PE(22:1(13Z)/P-18:1(9Z)); PE(20:3(8Z,11Z,14Z)/20:0); PE(20:3(8Z,11Z,14Z)/P-18:1(9Z)); PE(20:0/dm18:0); PI(O-20:0/18:3(9Z,12Z,15Z)); PE(18:3(6Z,9Z,12Z)/20:0); PE(20:3(5Z,8Z,11Z)/20:1(11Z); PI(20:3(8Z,11Z,14Z)/18:2(9Z,12Z)); PI(20:3(8Z,11Z,14Z)/18:1(11Z)); PI(17:1(9Z)/19:1(9Z)); PI(17:0/17:2(9Z,12Z)); LysoPE(0:0/20:4(8Z,11Z,14Z,17Z)); N-stearoyl serine; PE(22:1(13Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z)); |
