Study M614
Study name | Han YM 2020 |
Title | Urine metabolomic responses to aerobic and resistance training in rats under chronic unpredictable mild stress |
Overall design | The aim of this study was to investigate the effects of aerobic and resistance training on urinary metabolites by metabolomics analysis in the chronic unpredictable mild stress (CUMS) model of depression. Sprague-Dawley rats were divided into the following 4 groups (n = 8 per group): (1) control group, (2) CUMS group, (3) CUMS + aerobic training group (stressor plus aerobic training treatment at the dose of 25 mg/kg), and (4) CUMS + resistance training group (stressor plus resistance training treatment). The CUMS stress procedure lasted for 8 weeks, and exercise protocols were administered during the last 4 weeks of the model building period. Eight urine samples per group were used for NMR-based metabolomics analysis. |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Rat; Sprague-Dawley rat; |
Categories of depression | Animal model; Chronic mild stress model; Chronic mild stress model; |
Criteria for depression | Sucrose preference test |
Sample size | 32 |
Tissue | Peripheral; Urine; Urine; |
Platform | NMR; NMR: Bruker 600 MHz AVANCE III NMR spectrometer (Bruker Biospin, Rheinstetten, Germany); |
PMID | |
DOI | |
Citation | Han Y, Jia Y, Tian J, et al. Urine metabolomic responses to aerobic and resistance training in rats under chronic unpredictable mild stress. PLoS One. 2020;15(8):e0237377. |
Metabolite | Citric acid; Glycine; L-Glutamine; Hippuric acid; Creatinine; Oxoglutaric acid; Pyruvic acid; Creatine; Trimethylamine N-oxide; Acetic acid; Acetoacetic acid; Trimethylamine; |
