Study M612
Study name | Gules E 2020 |
Title | Plasma neuronal and glial markers and anterior cingulate metabolite levels in major depressive disorder: a pilot study |
Overall design | The aim of this study was to evaluate the markers of glial and neuronal cell turnover and to explore their associations with brain metabolites. Anterior cingulate cortex metabolites (N-acetyl aspartate, total choline and total creatine) were investigated in participants with major depressive disorder (MDD group, n = 10) and healthy controls (control group, n = 10) using proton magnetic resonance spectroscopy at 3T. Both mean absolute levels and mean ratios of metabolite to total creatine levels were compared. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Depression; Depression; |
Criteria for depression | DSM-IV diagnosed MDD |
Sample size | 20 |
Tissue | Central; Brain; Anterior cingulate cortex; |
Platform | MRS; MRS: Philips 3-T Achieva/Intera Release 2.6.1 12.6 series whole body scanning MR device (Philips Medical Systems, Eindhoven, The Netherlands); |
PMID | |
DOI | |
Citation | Gules E, Iosifescu DV, Tural U. Plasma neuronal and glial markers and anterior cingulate metabolite levels in major depressive disorder: a pilot study. Neuropsychobiology. 2020;79(3):214-221. |
Metabolite | N-Acetyl aspartate/(Creatine and Phosphocreatine) ratio; Choline-containing compounds/(Creatine and Phosphocreatine) ratio; |
