Study name | Geng CM 2020a |
Title | The impact of Dl-3-n-butylphthalide on the lipidomics of the hippocampus in a rat model of lipopolysaccharide-induced depression |
Overall design | In this study, an untargeted lipidomics approach of ultra-performance liquid chromatography coupled with mass spectrometry (UPLC-MS) was performed to reveal the potential discriminating lipid profile of the hippocampus for Dl-3-n-butylphthalide (NBP) involvement in lipopolysaccharide (LPS)-induced depression. Sprague-Dawley rats were divided into the following 3 groups (n = 6 in each group): (1) control group, (2) LPS group (500 ug/kg of LPS injection every other day for 14 days), and (3) LPS + NBP group (LPS injection plus Dl-3-n-butylphthalide treatment through oral gavage, 30 mg/kg/day for 14 days). |
Study Type  | Type1;
Type2;
|
Data available | Unavailable |
Organism | Rat; Sprague-Dawley rat;
|
Categories of depression | Animal model; Lipopolysaccharide induced depression model; Lipopolysaccharide induced depression model;
|
Criteria for depression | Sucrose preference test, forced swimming test |
Sample size | 18 |
Tissue | Central; Brain; Hippocampus;
|
Platform | MS-based; LC-MS: Ultimate 3000 (Dionex, USA) with Thermo Orbitrap Elite; |
PMID | 32464175 |
DOI | 10.1016/j.prostaglandins.2020.106464 |
Citation | Geng C, Hao G, Yi Q, et al. The impact of Dl-3-n-butylphthalide on the lipidomics of the hippocampus in a rat model of lipopolysaccharide-induced depression. Prostaglandins Other Lipid Mediat. 2020;150:106464. |
Metabolite | PC(38:6);
LysoPC(16:1/0:0);
PC(32:0);
LysoPE(0:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z));
PS(18:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z));
Cer(d18:1/16:0);
Cer(d18:1/18:0);
MG(0:0/20:4(5Z,8Z,11Z,14Z)/0:0);
LysoPC(20:4/0:0);
Cer(d18:0/18:0);
LysoPC(22:6(4Z,7Z,10Z,13Z,16Z,19Z)/0:0);
LysoPC(18:0/0:0);
PE(18:1(11Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z));
PC(20:5(5Z,8Z,11Z,14Z,17Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z));
PC(20:4(5Z,8Z,11Z,14Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z));
PS(16:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z));
PC(18:0/20:4(5Z,8Z,11Z,14Z));
LysoPE(0:0/20:5(5Z,8Z,11Z,14Z,17Z));
LysoPE(0:0/22:5(4Z,7Z,10Z,13Z,16Z));
PC(15:0/20:5(5Z,8Z,11Z,14Z,17Z));
Cer(d18:1/14:0);
PE(18:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z));
LysoPE(0:0/22:4(7Z,10Z,13Z,16Z));
PC(15:0/18:2(9Z,12Z));
PC(14:0/20:1(11Z));
PC(16:1(9Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z));
PE(16:0/20:5(5Z,8Z,11Z,14Z,17Z));
PE(18:0/20:5(5Z,8Z,11Z,14Z,17Z));
PE(18:1(11Z)/20:5(5Z,8Z,11Z,14Z,17Z));
PE(18:3(6Z,9Z,12Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z));
PE(14:0/20:0);
PE(14:0/20:3(5Z,8Z,11Z));
PE(14:1(9Z)/22:2(13Z,16Z));
PI(18:0/20:4(5Z,8Z,11Z,14Z));
PS(18:0/20:3(8Z,11Z,14Z));
PS(18:1(9Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z));
PS(20:4(5Z,8Z,11Z,14Z)/20:4(5Z,8Z,11Z,14Z));
PS(18:0/20:4(8Z,11Z,14Z,17Z));
PS(20:3(8Z,11Z,14Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z));
PS(22:6(4Z,7Z,10Z,13Z,16Z,19Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z));
TG(16:0/16:0/20:4(5Z,8Z,11Z,14Z));
TG(16:1(9Z)/14:0/16:1(9Z));
PC(15:0/16:0);
PC(16:0/18:1(11Z));
PC(18:2(9Z,12Z)/20:4(5Z,8Z,11Z,14Z));
PE(15:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z));
PE(18:1(11Z)/18:2(9Z,12Z));
PE(18:2(9Z,12Z)/20:4(5Z,8Z,11Z,14Z));
PE(18:0/22:5(4Z,7Z,10Z,13Z,16Z));
PG(18:1(11Z)/18:2(9Z,12Z));
PI(16:0/20:3(5Z,8Z,11Z));
PI(16:0/20:4(5Z,8Z,11Z,14Z));
PI(18:0/20:3(5Z,8Z,11Z));
PI(18:0/22:4(10Z,13Z,16Z,19Z));
PI(18:1(11Z)/20:4(5Z,8Z,11Z,14Z));
PI(16:0/18:1(11Z));
PI(16:0/22:3(10Z,13Z,16Z));
PS(16:0/18:1(9Z));
PS(18:1(9Z)/18:1(9Z));
PC(16:0/22:5(4Z,7Z,10Z,13Z,16Z));
PC(18:1(11Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z));
DG(18:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z)/0:0);
LysoPC(22:4(7Z,10Z,13Z,16Z)/0:0);
LysoPC(22:5(4Z,7Z,10Z,13Z,16Z)/0:0);
LysoPE(0:0/18:1(11Z));
LysoPE(0:0/20:4(5Z,8Z,11Z,14Z));
PC(18:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z));
PC(14:0/18:1(11Z));
PC(14:0/22:4(7Z,10Z,13Z,16Z));
PC(14:0/22:5(4Z,7Z,10Z,13Z,16Z));
PC(15:0/22:5(4Z,7Z,10Z,13Z,16Z));
PC(15:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z));
PC(16:1(9Z)/24:1(15Z));
PC(18:2(9Z,12Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z));
PC(20:2(11Z,14Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z));
PC(22:4(7Z,10Z,13Z,16Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z));
PC(22:2(13Z,16Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z));
PE(22:4(7Z,10Z,13Z,16Z)/20:4(5Z,8Z,11Z,14Z));
PE(15:0/22:0);
PE(P-16:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z));
PE(16:1(9Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z));
PE(18:0/22:4(7Z,10Z,13Z,16Z));
PE(22:5(4Z,7Z,10Z,13Z,16Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z));
PG(16:0/18:1(11Z));
PS(20:4(5Z,8Z,11Z,14Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z));
PS(18:0/18:1(9Z));
TG(16:0/16:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z));
TG(16:0/20:4(5Z,8Z,11Z,14Z)/20:4(5Z,8Z,11Z,14Z));
TG(18:1(9Z)/18:1(9Z)/20:3(5Z,8Z,11Z));
TG(18:1(9Z)/18:1(9Z)/20:4(5Z,8Z,11Z,14Z));
TG(18:1(9Z)/18:1(9Z)/22:4(7Z,10Z,13Z,16Z));
TG(18:1(9Z)/20:4(5Z,8Z,11Z,14Z)/20:4(5Z,8Z,11Z,14Z));
TG(20:4(5Z,8Z,11Z,14Z)/20:4(5Z,8Z,11Z,14Z)/20:4(5Z,8Z,11Z,14Z));
TG(20:4(5Z,8Z,11Z,14Z)/20:4(5Z,8Z,11Z,14Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z));
LysoPE(0:0/16:1(9Z));
PC(16:1(9Z)/14:0);
PE(22:5(4Z,7Z,10Z,13Z,16Z)/20:4(5Z,8Z,11Z,14Z));
PE(20:1(11Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z));
PG(16:1(9Z)/18:1(11Z));
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