Study M606
Study name | Gall Z 2020 |
Title | Effects of chronic cannabidiol treatment in the rat chronic unpredictable mild stress model of depression |
Overall design | The aim of this study was to reveal the effect of a long-term cannabidiol treatment in the chronic unpredictable mild stress (CUMS) model of depression. Wistar rats were divided into the following 3 groups (n = 12 in each group): (1) control group, (2) CUMS group, and (3) CUMS + cannabidiol group (stressor plus cannabidiol treatment at the dose of 10 mg/kg). The CUMS stress procedure lasted for 4 weeks, and drugs were administered via daily i.p. during the model building period. Hair corticosterone was assayed by liquid chromatography-mass spectrometry. |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Rat; Wistar rat; |
Categories of depression | Animal model; Chronic mild stress model; Chronic mild stress model; |
Criteria for depression | Sucrose preference test |
Sample size | 28 |
Tissue | Peripheral; Hair; Hair; |
Platform | MS-based; LC-MS: Agilent 1100 Series HPLC system with triple quadrupole mass spectrometer (Agilent Triple Quad G6410A, Agilent Technologies, Santa Clara, CA, USA); |
PMID | |
DOI | |
Citation | Gall Z, Farkas S, Albert A, et al. Effects of chronic cannabidiol treatment in the rat chronic unpredictable mild stress model of depression. Biomolecules. 2020;10(5):801. |
Metabolite |
