Study M605
Study name | Fritz M 2020 |
Title | Structural and biochemical imaging reveals systemic LPS-induced changes in the rat brain |
Overall design | The aim of this study was to measure in vivo structural and metabolic brain imaging of Fisher 344 rats at baseline and 2 h and 24 h following lipopolysaccharide (LPS) administration. Rats were divided into the following 2 groups: (1) control group (vehicle), and (2) LPS group (LPS i.p. at a dose of 0.83 mg/kg). For each group, rats at baseline, 2h post-injection, and 24h post-injection were used for MRS data analysis (n = 12 per group). Metabolite quantification conducted in the striatum and hippocampus was reported relative to brain water concentration. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Rat; Fisher 344 rat; |
Categories of depression | Animal model; Lipopolysaccharide induced depression model; Lipopolysaccharide induced depression model; |
Criteria for depression | Sucrose preference test, forced swimming test, tail suspension test |
Sample size | 24 |
Tissue | Central; Brain; Hippocampus; Central; Brain; Striatum; |
Platform | MRS; MRS: Bruker 70/16 US AVANCE III 7.0 T system (Karlsruhe, Germany); |
PMID | |
DOI | |
Citation | Fritz M, Klawonn AM, Qingyu Zhao Q, et al. Structural and biochemical imaging reveals systemic LPS-induced changes in the rat brain. J Neuroimmunol. 2020;348:577367. |
Metabolite |
