Study M597
Study name | Clark DL 2020 |
Title | Rostral anterior cingulate glutamate predicts response to subcallosal deep brain stimulation for resistant depression |
Overall design | The aim of this study was to investigate if rostral anterior cingulate (rACC) glutamate/glutamine concentration could serve as a potential biomarker of response for deep brain stimulation (DBS) treatment in treatment-resistant depression (TRD). Sixteen adults with TRD (major depression, n = 14; bipolar depression; n = 2). Glutamate and glutamine concentrations at baseline in the rACC were examined in relation to clinical outcomes at six months. Response was defined as a 50% reduction in HDRS from baseline to 6 months, and 6 were classified as responders (responder group) and 10 as non-responders (non-responder group). LCModel was used to calculate absolute metabolite concentrations (mmol/kg ww) for glutamate and glutamine. |
Study Type | Type4; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Treatment-resistant depression; Treatment-resistant depression; |
Criteria for depression | DSM-IV diagnosed MDD |
Sample size | 16 |
Tissue | Central; Brain; Rostral anterior cingulate; |
Platform | MRS; MRS: 3T General Electric Discovery 750; |
PMID | |
DOI | |
Citation | Clark DL, MacMaster FP, Brown EC, et al. Rostral anterior cingulate glutamate predicts response to subcallosal deep brain stimulation for resistant depression. J Affect Disord. 2020;266:90-94. |
Metabolite |
