Study M595
Study name | Cherix A 2020 |
Title | Metabolic signature in nucleus accumbens for anti-depressant-like effects of acetyl-L-carnitine |
Overall design | The aim of this study was to investigate the ability of acetyl-L-carnitine (LAC) supplementation to protect vulnerable mice against stress induced depressive-like behaviors. C57BL/6J mice were divided into the following 3 groups: (1) control group, (2) CRS group, and (3) CRS + acetyl-L-carnitine group (stressor plus acetyl-L-carnitine treatment at a concentration of 0.3% in the drinking water). The CRS stress procedure lasted for 3 weeks, and LAC was administered during the last week of the model building period. The metabolic impact in the nucleus accumbens of antidepressant LAC treatment in chronically stressed mice was investigated using 1H-magnetic resonance spectroscopy (n = 5-6 per group). Metabolite quantification was reported relative to brain water concentration. |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Mouse; C57BL/6J mouse; |
Categories of depression | Animal model; Chronic restraint stress model; Chronic restraint stress model; |
Criteria for depression | Forced swimming test, social interaction test |
Sample size | 16 |
Tissue | Central; Brain; Nucleus accumbens; |
Platform | MRS; MRS: horizontal 14.1T/26 cm Varian magnet (Agilent Inc, USA); |
PMID | |
DOI | |
Citation | Cherix A, Larrieu T, Grosse J, et al. Metabolic signature in nucleus accumbens for anti-depressant-like effects of acetyl-L-carnitine. Elife. 2020;9:e50631. |
Metabolite | N-Acetyl-L-aspartic acid; L-Glutamic acid; L-Glutamine; |
