Study M594

Study name

Chen X 2020

Title

Entorhinal cortex-based metabolic profiling of chronic restraint stress mice model of depression

Overall design

In this study, we used liquid chromatography-tandem mass spectrometry method to explore metabolic alterations in the entorhinal cortex (EC) of mice after exposed to chronic restraint stress (CRS). C57BL/6 mice were divided into the following 2 groups: (1) control group, and (2) CRS group. The CRS stress procedure lasted for 2 weeks. Eight samples per group were used for metabonomic analysis.

Study Type

Type1;

Data available

Unavailable

Organism

Mouse; C57BL/6 mouse;

Categories of depression

Animal model; Chronic restraint stress model; Chronic restraint stress model;

Criteria for depression

Sucrose preference test, forced swimming test

Sample size

16

Tissue

Central; Brain; Entorhinal cortex;

Platform

MS-based; LC-MS: Waters ultraperformance liquid chromatography (UPLC) with Waters Xevo TQS mass spectrometry system;

PMID

32074509

DOI

10.18632/aging.102798

Citation

Chen X, Lan T, Wang Y, et al. Entorhinal cortex-based metabolic profiling of chronic restraint stress mice model of depression. Aging. 2020;12(3):3042-3052.

Metabolite

L-Glutamic acid;

L-Aspartic acid;

Homovanillic acid;

L-Tyrosine;

Norepinephrine;

Ornithine;

5-Hydroxy-L-tryptophan;