Study M590
Study name | Ceylan D 2020 |
Title | Alterations in levels of 8-Oxo-2'-deoxyguanosine and 8-Oxoguanine DNA glycosylase 1 during a current episode and after remission in unipolar and bipolar depression |
Overall design | The aim of this study was to investigate changes in urine 8-Oxo-2’-deoxyguanosine (8-oxo-dG) and gene expression levels of 8-Oxoguanine DNA glycosylase 1 (OGG1) during a current depressive episode and after remission in bipolar and unipolar disorders. Twenty-four acutely depressed bipolar (BD group), 33 unipolar depression patients (MDD group) and 61 healthy controls (control group) were included in the study. Clinical evaluations, blood and urine sampling were completed at baseline and at remission after eight weeks. The urine 8-oxo-dG levels were assessed by liquid chromatography tandem mass spectrometry and adjusted for urine creatinine levels. |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Depression; Depression; |
Criteria for depression | DSM-IV-TR diagnosed MDD, HAMD-17 >= 18 |
Sample size | 94 |
Tissue | Peripheral; Urine; Urine; |
Platform | MS-based; LC-MS: HPLC system (Shimadzu, Kyoto, Japan) coupled to a triple quadrupole ion-trap mass spectrometer (4000QTRAP Applied Biosystems, CA, USA); |
PMID | |
DOI | |
Citation | Ceylan D, Yılmaz S, Tuna G, et al. Alterations in levels of 8-Oxo-2'-deoxyguanosine and 8-Oxoguanine DNA glycosylase 1 during a current episode and after remission in unipolar and bipolar depression. Psychoneuroendocrinology. 2020;114:104600. |
Metabolite |
