Study M588
Study name | Benson KL 2020 |
Title | 1 H MRS Measurement of cortical GABA and glutamate in primary insomnia and major depressive disorder: relationship to sleep quality and depression severity |
Overall design | The aim of this study was to compare regional proton magnetic resonance spectroscopy (1H MRS)-derived measures of GABA and glutamate in three groups: healthy, good sleeping controls (control group, n = 25), subjects with primary insomnia (PI group, n = 24), and subjects with major depressive disorder (MDD group, n = 51). Single-voxel proton magnetic resonance spectroscopy (1H MRS) at 4 Tesla was used to examine GABA + and glutamate relative to creatine in the dorsal anterior cingulate cortex and in the parieto-occipital cortex. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Depression; Depression; |
Criteria for depression | DSM-IV diagnosed MDD, HAM-D score >= 11 (not including insomnia items) |
Sample size | 76 |
Tissue | Central; Brain; Parieto-occipital cortex; Central; Brain; Dorsal anterior cingulate cortex; |
Platform | MRS; MRS: 4-Tesla MR scanner (Agilent Technologies; Santa Clara, CA); |
PMID | |
DOI | |
Citation | Benson KL, Bottary R, Schoerning L, et al. 1 H MRS Measurement of cortical GABA and glutamate in primary insomnia and major depressive disorder: relationship to sleep quality and depression severity. J Affect Disord. 2020;274:624-631. |
Metabolite |
