Study M575
Study name | Yang X 2019 |
Title | The internal link of serum steroid hormones levels in insomnia, depression, and Alzheimer's disease rats: Is there an effective way to distinguish among these three diseases based on potential biomarkers? |
Overall design | In this study, to investigate the internal connection and difference of steroid hormones among insomnia, depression, and Alzheimer's disease, and distinguish them from the perspective of biomarkers, an easy, quick, and efficient high-performance liquid chromatography with tandem mass spectrometry method was established and validated to determine six steroid hormones simultaneously in rat serum. Chronic unpredictable mild stress (CUMS) model of depression was established. Wistar rats were divided into the following 2 groups: (1) control group, and (2) CUMS group. The CUMS stress procedure lasted for 3 weeks. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Rat; Wistar rat; |
Categories of depression | Animal model; Chronic mild stress model; Chronic mild stress model; |
Criteria for depression | Not reported |
Sample size | 16 |
Tissue | Peripheral; Blood; Serum; |
Platform | MS-based; LC-MS: XR LC-20AD Prominence HPLC system (Shimadzu, Japan) with 4000 QTRAP MS/MS system (AB Sciex, Foster city, CA); |
PMID | |
DOI | |
Citation | Yang X, Wang Z, Zhang Q, et. The internal link of serum steroid hormones levels in insomnia, depression, and Alzheimer's disease rats: Is there an effective way to distinguish among these three diseases based on potential biomarkers? J Sep Sci. 2019;42(10):1833-1841. |
Metabolite |
