Study M572
Study name | Wu ZX 2019 |
Title | Biomarker screening for antenatal depression in women who underwent caesarean section: a matched observational study with plasma lipidomics |
Overall design | The aim of this study was to use lipidomics to identify potential biomarkers related to antenatal depression in women who have undergone caesarean section. A total of 66 subjects were recruited, including 33 subjects with major antenatal depression (major antenatal depression group) and 33 matched controls without antenatal depression (control group). Lipidomics of the plasma samples were performed using Ultra Performance Liquid Chromatography-mass spectrometry analysis to explore the differentially expressed lipids in women with or without antenatal depression. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Antenatal depressive disorder; Antenatal depressive disorder; |
Criteria for depression | DSM-V diagnosed major depression |
Sample size | 66 |
Tissue | Peripheral; Blood; Plasma; |
Platform | MS-based; LC-MS: HESI-II with Thermo Scientific Q Exactive hybrid quadruple Orbitrap mass spectrometer (Thermo Fisher Scientific, Waltham, MA, USA); |
PMID | |
DOI | |
Citation | Wu Z, Zhao P, Long Z, et al. Biomarker screening for antenatal depression in women who underwent caesarean section: a matched observational study with plasma lipidomics. BMC Psychiatry. 2019;19(1):259. |
Metabolite | 5-Aminopentanoic acid; SM(d18:1/16:0); LysoPE(0:0/18:2(9Z,12Z)); LysoPC(22:6(4Z,7Z,10Z,13Z,16Z,19Z)/0:0); LysoPC(20:3/0:0); SM(d16:1/18:0); 9Z-Heptatriacontene; LysoPC(16:0/0:0); EB 1213; 3alpha-Hydroxy-7-oxo-5alpha-cholan-24-oic Acid; Cholesterol sulfate; PC(18:2(2E,4E)/0:0); LMST03020057; LysoPC(0:0/18:0); 1-Hexanol; PE(13:0/22:1(11Z)); 1,25-Dihydroxy-23-oxo-vitamin D3; SM(d16:1/16:0); Undecanoic acid; SM(d18:1/15:0); Sorbitan stearate; SM(d16:1/20:1); PC(18:1(9Z)/0:0); PE(8:0/8:0); Etretinate; 13-amino-tridecanoic acid; 6-deoxyerythronolide B; PE(18:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z)); (7Z,10Z)-hexadecadienoylcarnitine; 12-amino-dodecanoic acid; 5-((5Z,8Z,11Z,14Z)-heptadeca-5,8,11,14-tetraen-1-yl)resorcinol; |
