Study M568

Study name

Vagena E 2019

Title

A high-fat diet promotes depression-like behavior in mice by suppressing hypothalamic PKA signaling

Overall design

The aim of this study was to investigate whether obesity is a causative factor for the development of depression and what is the molecular pathway(s) that link these two disorders. Using lipidomic and transcriptomic methods, the authors identified a mechanism that links exposure to a high-fat diet (HFD) in mice with alterations in hypothalamic function that lead to depression. C57BL/6J mice were divided into the following 2 groups: (1) control group (normal diet), (2) high-fat diet group (high-fat diet). Induction of depression-like behavior was observed after just 3 weeks and persisted at 8 weeks. Three to four samples per group were used for lipidomic analysis.

Study Type

Type1;

Data available

Unavailable

Organism

Mouse; C57BL/6J mouse;

Categories of depression

Animal model; Other animal model; Other animal model;

Criteria for depression

Sucrose preference test, forced swimming test, tail suspension test

Sample size

12

Tissue

Central; Brain; Cortex;

Central; Brain; Hypothalamus;

Platform

MS-based; GC-MS: Agilent 6890 GC system and Agilent 5973NMSD;

PMID

31076569

DOI

10.1038/s41398-019-0470-1

Citation

Vagena E, Ryu JK, Baeza-Raja B, et al. A high-fat diet promotes depression-like behavior in mice by suppressing hypothalamic PKA signaling. Transl Psychiatry. 2019;9(1):141.

Metabolite

Palmitic acid;