Study M567
Study name | Tillmann S 2019 |
Title | Behavioral and metabolic effects of S-adenosylmethionine and imipramine in the Flinders Sensitive Line rat model of depression |
Overall design | The present study investigated if S-adenosylmethionine (SAM) supplementation may correct liver SAM and behavioral abnormalities in Flinders Sensitive Line (FSL) rats, an animal model of depression, compared with the control rats, Flinders Resistant Line (FRL) rats. C1 metabolites in plasma (betaine, choline, dimethylglycine, homocysteine, cystathionine) and liver extracts were measured using UPLC-MS/MS. Ten samples in each group were used for UPLC-MS/MS. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Rat; Sprague-Dawley rat; |
Categories of depression | Animal model; Other animal model; Other animal model; |
Criteria for depression | Forced swimming test |
Sample size | 20 |
Tissue | Peripheral; Blood; Plasma; Peripheral; Liver; Liver; |
Platform | MS-based; LC-MS: Acquity Ultra Performance LC system with MicroMass Quattro Premier XE tandem quadrupole mass spectrometer (UPLC-MS/MS) (Waters Corporation, Milford, MA, USA); |
PMID | |
DOI | |
Citation | Tillmann S, Happ DF, Mikkelsen PF, et al. Behavioral and metabolic effects of S-adenosylmethionine and imipramine in the Flinders Sensitive Line rat model of depression. Behav Brain Res. 2019;364:274-280. |
Metabolite |
