Study M566
Study name | Tang MM 2019 |
Title | The status of omiga-3 PUFAs influence chronic unpredicted mild stress-induced metabolic side effects in rats through INSIG/SREBP pathway |
Overall design | The aim of the present study were to test whether chronic unpredicted mild stress (CUMS) induces lipid or other metabolic disturbances in rats. Maternal rats were randomly assigned to three groups: (deficiency, control and supplementary, n = 6-7 per group). Three or four male healthy offspring rats in each litter were randomly selected and assigned to two groups (control group and CUMS group). The fatty acid composition in liver was analyzed by LC-MS (n = 8-10). |
Study Type | Type1; |
Data available | Unavailable |
Organism | Rat; Sprague-Dawley rat; |
Categories of depression | Animal model; Chronic mild stress model; Chronic mild stress model; |
Criteria for depression | Sucrose preference test, forced swimming test |
Sample size | 50 |
Tissue | Peripheral; Liver; Liver; |
Platform | MS-based; LC-MS: Agilent 7890A/5975C equipped with VF-23 ms (Agilent); |
PMID | |
DOI | |
Citation | Tang M, Floyd S, Cai H, et al. The status of omiga-3 PUFAs influence chronic unpredicted mild stress-induced metabolic side effects in rats through INSIG/SREBP pathway. Food Funct. 2019;10(8):4649-4660. |
Metabolite |
