Study M565
Study name | Yang Q 2020 |
Title | Chronic minocycline treatment exerts antidepressant effect, inhibits neuroinflammation, and modulates gut microbiota in mice |
Overall design | The aim of this study was to detect the effects of chronic minocycline treatment on antidepression, neuroinflammation, and gut microbiota modulation in the chronic unpredictable mild stress (CUMS) mouse model of depression. C57BL/6 mice were divided into the following 3 groups: (1) control group, (2) CUMS group, and (3) CUMS + minocycline group (stressor plus minocycline treatment at the dose of 40 mg/kg). The CUMS stress procedure lasted for 6 weeks, and minocycline was administered intraperitoneally once per day during the last 4 weeks of model building period. The cecum and proximal colons were collected for gas chromatography mass spectrometry-based metabonomic analysis. |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Mouse; C57BL/6 mouse; |
Categories of depression | Animal model; Chronic mild stress model; Chronic mild stress model; |
Criteria for depression | Forced swimming test, tail suspension test |
Sample size | 22 |
Tissue | Peripheral; Gut; Intestine; |
Platform | MS-based; GC-MS: Agilent 7890A with Agilent 5975C MSD; |
PMID | |
DOI | |
Citation | Yang Q, Luo L, Sun T, et al. Chronic minocycline treatment exerts antidepressant effect, inhibits neuroinflammation, and modulates gut microbiota in mice. Psychopharmacology. 2020 Oct;237(10):3201-3213. |
Metabolite | Phosphoric acid; |
