Study M564
Study name | Song J 2019 |
Title | Metabolomic signatures and microbial community profiling of depressive rat model induced by adrenocorticotrophic hormone |
Overall design | In this study, an integrative gas chromatography-time-of-fight mass spectrometer (GC-TOFMS)-based urinary metabolomics was performed on chronic adrenocorticotropic hormone (ACTH)-treated rat model with depression phenotype to reveal the differentiated urinary metabolites. Wistar rats were divided into the following 2 groups (n = 10 in each group): (1) control group, and (2) ACTH group (s.c. injection of adrenocorticotropic hormone fragment 1-24, 100 ug/rat, 14 days). Six samples per group were used for metabonomic analysis. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Rat; Wistar rat; |
Categories of depression | Animal model; Other animal model; Other animal model; |
Criteria for depression | Forced swimming test, tail suspension test |
Sample size | 12 |
Tissue | Peripheral; Urine; Urine; |
Platform | MS-based; GC-MS: GC-TOFMS (Pegasus HT, Leco Corp., St. Joseph, MI; electron ionization mode); |
PMID | |
DOI | |
Citation | Song J, Ma W, Gu X, et al. Metabolomic signatures and microbial community profiling of depressive rat model induced by adrenocorticotrophic hormone. J Transl Med. 2019;17(1):224. |
Metabolite | myo-Inositol; |
