Study M557
Study name | Meyer JD 2019 |
Title | Serum endocannabinoid and mood changes after exercise in major depressive disorder |
Overall design | The aim of this study was to compare mood state and endocannabinoid responses to moderate and preferred-intensity aerobic exercise in major depressive disorder (MDD). Women with MDD (n = 17) exercised in separate sessions for 20 min on a cycle ergometer at both prescribed moderate (MOD) or self-selected/preferred (PREF) in a within-subjects design. Blood was drawn before and within 10 min after exercise. Serum concentrations of endocannabinoid (anandamide, 2-arachidonoylglycerol) and related lipids (palmitoylethanolamine, oleoylethanolamine, 2-oleoylglycerol) were quantified using stable isotope-dilution, liquid chromatography/mass spectrometry/mass spectrometry. The profile of mood states and state-trait anxiety inventory (state only) were completed before, 10 min and 30 min post-exercise. |
Study Type | Type2; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Depression; Depression; |
Criteria for depression | DSM-IV diagnosed MDD |
Sample size | 17 |
Tissue | Peripheral; Blood; Serum; |
Platform | MS-based; LC-MS: LC-ESI-MS-MS; |
PMID | |
DOI | |
Citation | Meyer JD, Crombie KM, Cook DB, et al. Serum endocannabinoid and mood changes after exercise in major depressive disorder. Med Sci Sports Exerc. 2019;51(9):1909-1917. |
Metabolite |
