Study M556
Study name | Ma WN 2019 |
Title | Chronic paradoxical sleep deprivation-induced depression-like behavior, energy metabolism and microbial changes in rats |
Overall design | The aim of this study was to examine the relationship between the microbiota and chronic paradoxical sleep deprivation (PSD)-induced behavioral and metabolic changes. Wistar rats were divided into the following 2 groups (n = 10 in each group): (1) control group, and (2) sleep deprivation group (seven days paradoxical sleep deprivation group). 7d-PSD rats displayed depression-like behavior. GC-MS based urine metabolomics was applied to estimate the influences of chronic PSD on host metabolism. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Rat; Wistar rat; |
Categories of depression | Animal model; Other animal model; Other animal model; |
Criteria for depression | Sucrose preference test, forced swimming test, tail suspension test |
Sample size | 16 |
Tissue | Peripheral; Urine; Urine; |
Platform | MS-based; GC-MS: Agilent 7890B/5977A, GC/MSD system; |
PMID | |
DOI | |
Citation | Ma W, Song J, Wang H, et al. Chronic paradoxical sleep deprivation-induced depression-like behavior, energy metabolism and microbial changes in rats. Life Sci. 2019;225:88-97. |
Metabolite | Citric acid; Glycine; L-Lactic acid; L-Alanine; L-Lysine; Suberic acid; Threonic acid; Creatinine; Uric acid; Ascorbic acid; Niacinamide; Glycolic acid; |
