Study M551

Study name

Liu BY 2019

Title

Association between plasma concentrations of elaidic acid, a major trans fatty acid, and depression in a nationally representative sample of U.S. adults

Overall design

In this study, the authors examined the associations of objectively-measured plasma trans fatty acid concentrations with depression in a large population-based cross-sectional study among U.S. adults. The final sample consisted of 2136 participants, including 203 participants with depressive symptom (depression group, PHQ-9 >= 10) and 1933 participants without depressive symptom (control group, PHQ-9 < 10). Four major trans fatty acid isomers, including palmitelaidic acid, elaidic acid, vaccenic acid, and linoelaidic acid, were measured in fasting plasma samples using gas chromatography/mass spectrometry.

Study Type

Type1;

Data available

Unavailable

Organism

Human;

Categories of depression

Depressive symptom; Depressive symptom; Depressive symptom;

Criteria for depression

PHQ-9 >= 10

Sample size

2136

Tissue

Peripheral; Blood; Plasma;

Platform

MS-based; GC-MS: not reported;

PMID

30797122

DOI

10.1016/j.jad.2019.02.032

Citation

Liu B, Sun Y, Xu G, et al. Association between plasma concentrations of elaidic acid, a major trans fatty acid, and depression in a nationally representative sample of U.S. adults. J Affect Disord. 2019;249:301-306.

Metabolite

Elaidic acid;