Study M545
Study name | Huang NN 2019 |
Title | Contribution of skeletal muscular glycine to rapid antidepressant effects of ketamine in an inflammation-induced mouse model of depression |
Overall design | The present study employed metabolomics and sequencing analysis in lipopolysaccharide (LPS)-induced mouse models of depression to investigate the contribution of the skeletal muscular glycine signaling in antidepressant effects of ketamine. C57BL/6 mice were divided into the following 3 groups (n = 8 in each group): (1) control group, (2) LPS group (LPS plus vehicle treatment), and (3) LPS + ketamine group (LPS plus ketamine treatment). Ketamine (10 mg/kg, i.p.) or equal volume of vehicle was singly administered after 1 h of LPS (0.5 mg/kg, i.p.) administration. Behavioral assessments, including the locomotion test (24 h after LPS administration), tail suspension test (26 h after LPS administration), and forced swimming test (2 h after TST or 24 h after LPS administration), were performed. |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Mouse; C57BL/6 mouse; |
Categories of depression | Animal model; Lipopolysaccharide induced depression model; Lipopolysaccharide induced depression model; |
Criteria for depression | Tail suspension test, forced swimming test |
Sample size | 24 |
Tissue | Peripheral; Muscle; Skeletal muscle; |
Platform | MS-based; GC-MS: not reported; |
PMID | |
DOI | |
Citation | Huang N, Wang Y, Zhan G, et al. Contribution of skeletal muscular glycine to rapid antidepressant effects of ketamine in an inflammation-induced mouse model of depression. Psychopharmacology. 2019;236(12):3513-3523. |
Metabolite |
