Study M544
Study name | Hu ZC 2019 |
Title | Objective diagnosis of post-stroke depression using NMR-based plasma metabonomics |
Overall design | In this study, a proton nuclear magnetic resonance (H NMR)-based metabonomic approach was employed to profile plasma samples from 32 post-stroke depression (PSD group), 35 stroke patients (stroke group) and 35 healthy comparison subjects (control group) in order to identify metabolite biomarkers for PSD (the training set). Then, 10 PSD, 11 stroke patients and 11 healthy comparison subjects (test set) were used to validate the diagnostic performance of these biomarkers. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Post-stroke depression; Post-stroke depression; |
Criteria for depression | DSM-5 diagnosed major depression and minor depression, HAMD-17 > 8 |
Sample size | 134 |
Tissue | Peripheral; Blood; Plasma; |
Platform | NMR; NMR: Bruker Avance 600 spectrometer; |
PMID | |
DOI | |
Citation | Hu Z, Fan S, Liu M, et al. Objective diagnosis of post-stroke depression using NMR-based plasma metabonomics. Neuropsychiatr Dis Treat. 2019;15:867-881. |
Metabolite |
