Study M538
Study name | Erbay MF 2019 |
Title | Evaluation of transcranial magnetic stimulation efficiency in major depressive disorder patients: a magnetic resonance spectroscopy study |
Overall design | This study evaluated the antidepressant effect of repetitive transcranial magnetic stimulation (rTMS) and examined how it affected N-asetyl aspartate, choline, creatine, lactate, myoinositol, glutamate, glutathione, and glutamine metabolite levels in the left dorsolateral prefrontal cortex (DLPFC) of major depressive disorder (MDD) patients who were not receiving antidepressant medication. Twenty-three MDD patients underwent H magnetic resonance spectroscopy before and within 3 days of completing TMS therapy. All patients completed 20 sessions of rTMS directed to the left DLPFC over a 2-week period. For metabolite quantification, the peak area was normalized by the total phosphorous signal. Eighteen patients were evaluated for the analysis. |
Study Type | Type2; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Depression; Depression; |
Criteria for depression | DSM-5 diagnosed MDD |
Sample size | 18 |
Tissue | Central; Brain; Dorsolateral prefrontal cortex; |
Platform | MRS; MRS: 3T MR device (Magnetom Skyra-Siemens, Erlangen, Germany); |
PMID | |
DOI | |
Citation | Erbay MF, Zayman EP, Erbay LG, et al. Evaluation of transcranial magnetic stimulation efficiency in major depressive disorder patients: a magnetic resonance spectroscopy study. Psychiatry Investig. 2019;16(10):745-750. |
Metabolite | N-Acetyl aspartate/(Creatine and Phosphocreatine) ratio; |
