Study M537
Study name | Du HX 2019 |
Title | Microglial activation and neurobiological alterations in experimental autoimmune prostatitis-induced depressive-like behavior in mice |
Overall design | The aim of this study was to determine the role of hippocampal microglial activation and neurobiological changes in a mouse model of experimental autoimmune prostatitis (EAP)-induced depression. Mice were divided into the following 2 groups (n = 10 in each group): (1) control group, and (2) experimental autoimmune prostatitis group. Mice in each group were tested for tactile allodynia every ten days after the initial immunization. One week after the secondary immunization, mice received behavioral tests and MRI measurements. Metabolite quantification was reported relative to total creatine as the reference peak. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Mouse; NOD/ShiLtJ mouse; |
Categories of depression | Animal model; Other animal model; Other animal model; |
Criteria for depression | Forced swim test, tail suspension test |
Sample size | 20 |
Tissue | Central; Brain; Hippocampus; |
Platform | MRS; MRS: Bruker 9.4 T MRI scanner (Bruker BioSpin MRI, Ettlingen, Germany); |
PMID | |
DOI | |
Citation | Du HX, Chen XG, Zhang L, et al. Microglial activation and neurobiological alterations in experimental autoimmune prostatitis-induced depressive-like behavior in mice. Neuropsychiatr Dis Treat. 2019;15:2231-2245. |
Metabolite | (Glutamate and Glutamine)/(Creatine and Phosphocreatine) ratio; |
