Study M536
Study name | Deng FL 2019 |
Title | Metabonomics reveals peripheral and central short-chain fatty acid and amino acid dysfunction in a naturally occurring depressive model of macaques |
Overall design | In this study, using our previously established naturally occurring depressive (NOD) model in a non-human primate (cynomolgus monkey, Macaca fascularis), we performed metabolomics analysis of cerebrospinal fluid (CSF) from NOD female macaques (naturally-occurring depression group, N=10) and age- and gender-matched healthy controls (control group, N=12). |
Study Type | Type1; |
Data available | Unavailable |
Organism | Non-human primate; Cynomolgus monkey; |
Categories of depression | Animal model; Other animal model; Other animal model; |
Criteria for depression | Behavioral observation |
Sample size | 22 |
Tissue | Central; Cerebrospinal fluid; Cerebrospinal fluid; |
Platform | MS-based; GC-MS: Agilent 7890A/5975C GC-MS system (Agilent Technologies Inc., USA); |
PMID | |
DOI | |
Citation | Deng FL, Pan JX, Zheng P, et al. Metabonomics reveals peripheral and central short-chain fatty acid and amino acid dysfunction in a naturally occurring depressive model of macaques. Neuropsychiatr Dis Treat. 2019;15:1077-1088. |
Metabolite | myo-Inositol; Oleic acid; Stearic acid; Palmitic acid; L-Proline; Glycine; L-Threonine; L-Aspartic acid; D-Fructose; Hydroxylamine; Acetic acid; D-Xylitol; Beta-Alanine; Elaidic acid; 2-Keto-D-gluconic acid; N-Acetyl-D-glucosamine; Malonic acid; Erythronic acid; Heptadecanoic acid; Ribitol; Putrescine; Methylamine; Phenylacetic acid; Butyric acid; D-Threitol; Scyllitol; Propionic acid; Thiourea; Pelargonic acid; Carbamic acid; Glucaric acid; |
