Study M535

Study name

Colic L 2019b

Title

Rostral anterior cingulate glutamine/glutamate disbalance in major depressive disorder depends on symptom severity

Overall design

In this study, major depressive disorder patients (MDD group, n = 32) and control subjects (control group, n = 32) were compared for pregenual anterior cingulate cortex levels of glutamine / glutamate, glutamine / total creatine (tCr), glutamate / tCr, and gamma-aminobutyric acid / tCr as determined by high-field magnetic resonance spectroscopy.

Study Type

Type1;

Data available

Unavailable

Organism

Human;

Categories of depression

Depressive disorder; Depression; Depression;

Criteria for depression

ICD-10 diagnosed MDD

Sample size

64

Tissue

Central; Brain; Pregenual anterior cingulate cortex;

Platform

MRS; MRS: 7T MR scanner (Siemens Healthineers, Erlangen, Germany);

PMID

31202822

DOI

10.1016/j.bpsc.2019.04.003

Citation

Colic L, von During F, Denzel D, et al. Rostral anterior cingulate glutamine/glutamate disbalance in major depressive disorder depends on symptom severity. Biol Psychiatry Cogn Neurosci Neuroimaging. 2019;4(12):1049-1058.

Metabolite

Glutamine/Glutamate ratio;